TEF1 Rabbit Polyclonal Antibody

Function :
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC ‘enhansons’ (5′-GTGGAATGT-3′) and activates transcription in vivo in a cell-specific manner.725728-43-8 web The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF).(S)-3-Phenylpyrrolidine hydrochloride Price Involved in cardiac development.PMID:33484399 Binds to the M-CAT motif.