Damitsu C, Nishitoh H, Nagai S, Koyasu S, Matsumoto K, Takeda K, Ichijo H: ROS-dependent activation on the TRAF6-ASK1-p38 pathway is selectively expected for TLR4-mediated innate immunity. Nat Immunol 2005, 6:587?92. 43. Yong HY, Koh MS, Moon A: The p38 MAPK inhibitors for the therapy of inflammatory diseases and cancer. Specialist Opin Investig Medicines 2009, 18:1893?905.44. Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M: The 2 faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but greater community injury following intestinal ischemia-reperfusion. Nat Med 2003, 9:575?81. 45. Otsu K, Yamashita N, Nishida K, Hirotani S, Yamaguchi O, Watanabe T, Hikoso S, Higuchi Y, Matsumura Y, Maruyama M, et al: Disruption of a single copy on the p38alpha MAP kinase gene results in cardioprotection towards ischemia-reperfusion. Biochem Biophys Res Commun 2003, 302:56?0. 46. Neubert M, Ridder DA, Bargiotas P, Akira S, Schwaninger M: Acute inhibition of TAK1 protects towards neuronal death in cerebral ischemia. Cell Death Differ 2011, 18:1521?530. 47. Martindale JL, Holbrook NJ: Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 2002, 192:1?5. 48. Wang X, Xu L, Wang H, Younger PR, Gaestel M, Feuerstein GZ: Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic damage in mice. J Biol Chem 2002, 277:43968?3972. 49. Martindale JJ, Wall JA, Martinez-Longoria DM, Aryal P, Rockman HA, Guo Y, Bolli R, Glembotski CC: Overexpression of mitogen-activated protein kinase kinase six during the heart improves functional recovery from ischemia in vitro and protects towards myocardial infarction in vivo.867065-85-8 Chemical name J Biol Chem 2005, 280:669?76.183070-44-2 Order 50.PMID:33577404 Nachbaur K, Troppmair J, Bieling P, Kotlan B, Konig P, Huber C: Cytokines during the control of beta-2 microglobulin release. I. In vitro scientific studies on a variety of haemopoietic cells. Immunobiology 1988, 177:55?five. 51. Halawa A: The early diagnosis of acute renal graft dysfunction: a challenge we face. The position of novel biomarkers. Ann Transplant 2011, sixteen:90?8. 52. Sumimoto H: Structure, regulation and evolution of Nox-family NADPH oxidases that create reactive oxygen species. Febs J 2008, 275:3249?277. 53. Singer E, Marko L, Paragas N, Barasch J, Dragun D, Muller DN, Budde K, Schmidt-Ott KM: Neutrophil gelatinase-associated lipocalin: pathophysiology and clinical applications. Acta Physiol (Oxf) 2013, 207:663?72. 54. Jiang F, Zhang Y, Dusting GJ: NADPH oxidase-mediated redox signaling: roles in cellular pressure response, anxiety tolerance, and tissue restore. Pharmacol Rev 2011, 63:218?42. fifty five. Darwish RS, Amiridze N, Aarabi B: Nitrotyrosine as an oxidative strain marker: evidence for involvement in neurologic outcome in human traumatic brain damage. J Trauma 2007, 63:439?42. 56. Shiroto K, Otani H, Yamamoto F, Huang CK, Maulik N, Das DK: MK2-/- gene knockout mouse hearts carry anti-apoptotic signal and are resistant to ischemia reperfusion injury. J Mol Cell Cardiol 2005, 38:93?seven. 57. Claycomb WC, Lanson NA Jr, Stallworth BS, Egeland DB, Delcarpio JB, Bahinski A, Izzo NJ Jr: HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic traits with the adult cardiomyocyte. Proc Natl Acad Sci U S A 1998, 95:2979?984. 58. White SM, Constantin PE, Claycomb WC: Cardiac physiology on the cellular degree: use of cultured HL-1 cardiomyocytes for scientific studies of cardiac muscle cell structure and function. Am J Physiol Heart Circ Physi.